Tyck till om SwePub Sök
här!
Search: WFRF:(Johnsson Ellinor)
> Gudbjartsson Daníel F
> Ingelsson Erik >
Variants in ELL2 in...
Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.
-
- Swaminathan, Bhairavi (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
-
Thorleifsson, Guðmar (author)
-
- Jöud, Magnus (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
-
show more...
-
- Ali, Mina (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
-
- Johnsson, Ellinor (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
-
- Ajore, Ram (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
-
Sulem, Patrick (author)
-
- Halvarsson, Britt-Marie (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
-
Eyjolfsson, Guðmundur (author)
-
Haraldsdottir, Vilhelmina (author)
-
- Hultman, Christina (author)
- Karolinska Institutet
-
- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi
-
- Kristinsson, Sigurður Y (author)
- Karolinska Institutet
-
- Kähler, Anna K (author)
- Karolinska Institutet
-
- Lenhoff, Stig (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
-
Masson, Gisli (author)
-
Mellqvist, Ulf-Henrik (author)
-
- Månsson, Robert (author)
- Karolinska Institutet
-
- Nelander, Sven (author)
- Uppsala universitet,Neuroonkologi
-
Olafsson, Isleifur (author)
-
Sigurðardottir, Olof (author)
-
Steingrimsdóttir, Hlif (author)
-
Vangsted, Annette (author)
-
Vogel, Ulla (author)
-
Waage, Anders (author)
-
- Nahi, Hareth (author)
- Karolinska Institutet
-
Gudbjartsson, Daniel F (author)
-
Rafnar, Thorunn (author)
-
- Turesson, Ingemar (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
-
- Gullberg, Urban (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
-
Stefánsson, Kári (author)
-
- Hansson, Markus (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
-
Thorsteinsdóttir, Unnur (author)
-
- Nilsson, Björn (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
-
show less...
-
(creator_code:org_t)
- 2015-05-26
- 2015
- English.
-
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6, s. 1-8
- Related links:
-
https://portal.resea... (primary) (free)
-
show more...
-
http://www.ncbi.nlm....
-
http://dx.doi.org/10... (free)
-
https://www.nature.c...
-
https://doi.org/10.1...
-
https://uu.diva-port... (primary) (Raw object)
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Multiple myeloma (MM) is characterized by an uninhibited, clonal growth of plasma cells. While first-degree relatives of patients with MM show an increased risk of MM, the genetic basis of inherited MM susceptibility is incompletely understood. Here we report a genome-wide association study in the Nordic region identifying a novel MM risk locus at ELL2 (rs56219066T; odds ratio (OR)=1.25; P=9.6 × 10(-10)). This gene encodes a stoichiometrically limiting component of the super-elongation complex that drives secretory-specific immunoglobulin mRNA production and transcriptional regulation in plasma cells. We find that the MM risk allele harbours a Thr298Ala missense variant in an ELL2 domain required for transcription elongation. Consistent with a hypomorphic effect, we find that the MM risk allele also associates with reduced levels of immunoglobulin A (IgA) and G (IgG) in healthy subjects (P=8.6 × 10(-9) and P=6.4 × 10(-3), respectively) and, potentially, with an increased risk of bacterial meningitis (OR=1.30; P=0.0024).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Swaminathan, Bha ...
-
Thorleifsson, Gu ...
-
Jöud, Magnus
-
Ali, Mina
-
Johnsson, Ellino ...
-
Ajore, Ram
-
show more...
-
Sulem, Patrick
-
Halvarsson, Brit ...
-
Eyjolfsson, Guðm ...
-
Haraldsdottir, V ...
-
Hultman, Christi ...
-
Ingelsson, Erik
-
Kristinsson, Sig ...
-
Kähler, Anna K
-
Lenhoff, Stig
-
Masson, Gisli
-
Mellqvist, Ulf-H ...
-
Månsson, Robert
-
Nelander, Sven
-
Olafsson, Isleif ...
-
Sigurðardottir, ...
-
Steingrimsdóttir ...
-
Vangsted, Annett ...
-
Vogel, Ulla
-
Waage, Anders
-
Nahi, Hareth
-
Gudbjartsson, Da ...
-
Rafnar, Thorunn
-
Turesson, Ingema ...
-
Gullberg, Urban
-
Stefánsson, Kári
-
Hansson, Markus
-
Thorsteinsdóttir ...
-
Nilsson, Björn
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Hematology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Nature Communica ...
- By the university
-
Lund University
-
Uppsala University
-
Karolinska Institutet